| Notes |
Chemical modifications to mRNAs change the topologies and chemistries accessible to these biomolecules, potentially altering their biogenesis, localization, function, and stability. The Koutmou laboratory is working to ascertain how mRNA modifications impact protein synthesis. We are tackling this challenge from two perspectives: from the level of the modification itself (how, where, and which modifications are incorporated), and from the viewpoint of the ribosome which ‘reads’ the modification. |
